BCRB 2018

Randomized trials on dose painting / dose escalation in locally advanced HNSCC

Acronym

Stage

Molecular imaging

Design

Due date

Xuzhou Medical College, China

F-Miso PET and FDG-PET

RT-CH >< dose escalation on FDG >< dose escalation on F-Miso

III-IV§

Dec J015?

De Neve*

II-IV

FDG-PET

69 Gy IMRT >< 84 Gy IMRT

Q1 2018

Eisbruch*

70 Gy + carbo/cddp >< 80 Gy + carbo/cddp

III-IV

DCE-MRI

Dec 2020

INTELHOPE*

66 Gy + cddp >< 73.5 Gy + cddp

III-IV

FDG-PET

Dec 2020

Zips*

Dec 2022

III-IV

F-Miso PET

70 Gy + CH >< 77 Gy +CH

Escalox (Munich)

70 Gy + CDDP (w1, w5) >< 80.6 Gy + CDDP (w1, w5)

III

F-Miso PET

> July 2015

§ nasopharyngeal carcinoma * randomized phase-II

ESTRO 2018

ClinicalTrials.gov, April 2017