BCRB 2018

19/09/2018

Why assess adverse effects?

• To facilitate the evaluation of new cancer therapies, treatment modalities and supportive measures • To monitor safety data • To aid in the recognition of severe toxicity & to ensure regulatory reporting

• Essential to standardize reporting • Within and across treatment modalities • Between investigators, institutions and studies

5

Why assess adverse effects?

• To assess the therapeutic ratio • eg change in treatment strategy

Probability of Tumor Control

1

Probability of Normal Tissue Damage

Therapeutic Effect (A)

Max. Tolerance

Response probability

0

A

Dose (Gy)

6