BCRB 2018

19/09/2018

Small bowel toxicity

• Acute toxicity • Results of cell death in proliferative compartment • Failure to replace the villus epithelium • Shortening of the villus • Endothelial cell swelling and loss with increased vascular permeability • Breakdown of the mucosal barrier • Mucositis

Consequential late effects

Dörr, Radiother Oncol 2001

Impairment of barrier function