BCRB 2018

19/09/2018

Relevant factors

• Organs in the irradiated volume • Normal tissue constraints • Pathogenesis of functional tissue (L1.7) • Vascular component • Connective tissue • Specific functional tissue compartments • Previous irradations • Retreatment tolerance (L4.5)

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Relevant factors

• Patient -related factors influencing normal tissue reactions • Age • Co-morbidity (e.g. cardiovascular diseases, diabetes) • Genetic syndromes (e.g. Ataxia Telangiectasia) • Infection (e.g. IBD, Crohn’s disease) • Interaction with other treatments (e.g. chemotherapy) • Patient’s general condition • Smoking

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