BCRB 2018

19/09/2018

Relevant radiobiology factors

• Irradiated volume with SBRT

Dunlap Int J Radiat Oncol 2010 60 pts

60 patients

The median interval to onset 7.1 months

Chest wall volume receiving >30Gy in 3 to 5 fractions predicts risk of severe pain and/or rib fracture after lung SBRT

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Relevant factors

• Radiobiology -related factors influencing normal tissue reactions • Intrinsic radiosensitivity • Total radiation dose • Technique and irradiated volume

• Fractionation schedule (late reactions) • Overall treatment time (early reactions) • Concomitant treatment

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