BCRB 2018

19/09/2018

Relevant factors

• Radiobiology -related factors influencing normal tissue reactions • Intrinsic radiosensitivity • Total radiation dose • Technique and irradiated volume

• Fractionation schedule (late reactions) • Overall treatment time (early reactions) • Concomitant treatment

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Relevant radiobiology factors

• Overall treatment time

HNSCC CHART : 54Gy/36fx in 12 consecutive days Conventional: 66Gy/33fx in 6.5 weeks

CHART

Shorter OTT resulted in aggravation of early side effects

Conventional

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Dische 1997