BCRB 2018

Curtis' LPL model

Viable cells (no lesions)

Curtis SB. Radiat Res 1986;106:252

Correct repair

ε PL

η PL

Lesions produced by irradiation

η L

Potentially lethal (i.e. repairable) lesions Simple DSB

Complex DSB α

β

Binary misrepair

Lethal lesions (cell death)

ε 2PL

Michael Joiner

Basic Clinical Radiobiology 2018

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