BCRB 2018

19/09/2018

Local tumor control assay

• Irradiation of tumors in vivo • Groups of tumors, different dose levels (graded doses) • Follow up: local control or recurrence • Evaluation of local control rates for each dose level • Construction of dose response curves

Tumor Control (Cure) – TCD50

• The radiation dose

which cures 50% of a homogeneous population of tumors (TCD50) is estimated. directly assesses the sensitivity of the stem cell population in the tumor.

• This assay most

Basic clinical radiobiology