BCRB 2018

19/09/2018

Killing all cancer stem cells is necessary for local tumour control

Baumann, Krause, Hill, Nature Rev Cancer 545-554, 2008

Summary TCD50 assay

• Best assay available for experimental radiotherapy • Most relevant for clinical practice • Tumour cells remain in situ • Dependent only on clonogenic cells • All clonogenic cells are assayed, not only some logs • Thus also survival of small resistant subgroups of clonogens can be assayed • Good for radiobiological modelling