BCRB 2018

Late effect signaling

TGF-a,ß , TNF-a MCP-1, MIP-1a PDGF, RANTES VEGF

Epithelium

ICAM-1

Makro- phages

ROS/ RNOS

Endo- thelium

IL-6 MCP-1 MIP-1a

bFGF, PDGF IGF-1, IL-1ß IL-8 , MCP-1 MIP-1a, RANTES TNF-a, TGF-ß

Fibroblasts

collagen fibronectin

bFGF, collagenase GM-CSF, IL-1ß IL-6 , PDGF PGE2 , VEGF

Dörr and Herrmann, In: Nieder et al. (Eds.), Springer-Verlag 2003

ESTRO BCR Course / Pathogenesis of NT effects – W. Dörr