BCRB 2018

1 /n

d 16.5 10.95

0

1.0 .5

0.2

0.4

αβ = 3 Gy

.25 .125 .0625 .03125 .015625

7.35 4.88 3.14 1.90 1.08

1 /n

0.6

α/β

0.8

Proportion of full effect

1.0

0

5

10

15

20

d

Dose per fraction (Gy)

Damage from a single fraction = αd + βd  2 Total damage from n fractions, E = n ( αd + βd  2 ) E/n = αd + βd  2 1 /n = ( α/E)d + ( β/E)d  2

Michael Joiner

Basic Clinical Radiobiology 2018

Page 10 of 27