BCRB 2018
Table 10.1: α/β values for human normal tissues and tumors Tissue/organ Endpoint α/β (Gy) 95% CL (Gy) Source Early reactions Skin Erythema 8.8 6.9; 11.6 Turesson and Thames (1989) Erythema 12.3 1.8; 22.8 Bentzen et al. (1988) Dry desquamation ~ 8 N/A Chogule and Supe (1993) Desquamation 11.2 8.5; 17.6 Turesson and Thames (1989) Oral mucosa Mucositis 9.3 5.8; 17.9 Denham et al. (1995) Mucositis 15 –15; 45 Rezvani et al. (1991) Mucositis ~ 8 N/A Chogule and Supe (1993)
Telangiectasia Telangiectasia Telangiectasia Telangiectasia Mean Late 2.9 Mean Early 10.6 H&N, Lung tumors high , Breast, Prostate tumors low 2.8 2.6 2.8 3.8 1.7 3.5 4.0 4.7 3.5 1.7; 3.8 2.2; 3.3 –0.1; 8.1 1.8; 5.7 0.6; 2.6 0.7; 6.4 2.3; 5.6 2.4; 7.0 0.7; 6.2 Fibrosis Cosmetic change in appearance Induration (fibrosis) Breast Oedema Impaired shoulder movement Brachial plexopathy Brachial plexopathy Optic neuropathy <3.5 N/A N/A ~ 2 1.6 –7; 10 Myelopathy Corneal injury <3.3 N/A Stricture/perforation Various late effects Pneumonitis
Late reactions Skin/vasculature
Turesson and Thames (1989) Bentzen et al. (1990) Bentzen and Overgaard (1991) Haviland et al. (2013) Bentzen and Overgaard (1991)
Subcutis Breast
Haviland et al. (2013) Haviland et al. (2013) Haviland et al. (2013) Bentzen et al. (1989) Olsen et al. (1990) Powell et al. (1990) Jiang et al. (1994) Dische et al. (1981) Jiang et al. (1994) Deore et al. (1993) Dische et al. (1999) Bentzen et al. (2000) Dubray et al. (1995) Rezvani et al. (1991)
Muscle/vasculature/cartilage
Nerve
Spinal cord
Eye Bowel
2.9 3.9 4.3 4.0 3.1 3.5 4.0 3.8 0.8
–4; 10 2.5; 5.3 2.2; 9.6 2.2; 5.8 –0.2; 8.5 1.1; 5.9 3.3; 5.0 0.8; 14 –0.6; 2.5 6.5; 29 4.9; 24 ‘ Wide ’ 2.9; ∞ 3.6; ∞ –11; 43 7.0; 9.4 4.5; 11.3 1.6; 3.8 1.2; 5.7 1.5; 17 –1.1; 2.5 –1.4; 5.4
Lung
Lung fibrosis (radiological) Various late effects Various late effects Various late effects Various late effects
Head and neck
Stuschke and Thames (1999) Maciejewski et al. (1986) Maciejewski et al. (1990)
Supraglottic larynx Oral cavity + oropharynx
Tumours Head and neck Various
10.5 14.5 ~ 13 6.6 7.2
Stuschke and Thames (1999) Rezvani et al. (1993) Robertson et al. (1993) Maciejewski et al. (1989) Maciejewski et al. (1989)
Larynx
Vocal cord Buccal mucosa
Tonsil
Nasopharynx
16 8.2 8.5 2.7 3.5 4.9 0.6 0.4
Lee et al. (1995)
Lung (NSCLC, early)
Studchke and Pöttgen (2010)
Skin
Trott et al. (1984)
Prostate Breast
Vogelius and Bentzen (2018) Haviland et al. (2013) Geh et al. (2006) Bentzen et al. (1989) Thames and Suit (1986)
Oesophagus Melanoma Liposarcoma
Michael Joiner
Basic Clinical Radiobiology 2018
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