BCRB 2018
Repopulation: Mechanisms
vascular effects,
stem cell depletion
tissue hypoplasia
inflammation, macrophages
EGF-R ICAM-1
?!?
stem cells asymmetry loss
sterilised cells abortive divisions
stem cells acceleration
TGF-a (early) EGF (late) KGF
EGF KGF
compensation of cell loss
dose compensation
ESTRO BCR Course / NT overall treatment time – W. Dörr
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