BCRB 2018

Intra and Inter tumor heterogeneity

Normal tissue

20

15

10

5

0

0 Relative frequency (%) 20 40

Nordsmark et al. Acta Oncol 1994

60

80

Oxygen partial pressure (mmHg)

100

80

20

Tumour

60

15

40

10

20

Dead (n=42) Alive (n=24)

5

Fraction pO 2 < 2.5 mmHg (%) 0 10 20 30 40 50 60 70 80 90 100 Relative frequency patients (%) 0

0

Relative frequency (%) 0 20

40

60

80

Oxygen partial pressure (mmHg)