BCRB 2018

Consequences of spatial heterogeneity w Hypoxia can exist around all vessels in a tumor • Hypoxia exists in small tumors! w Oxygenation varies at the cellular (micron) level w Imaging hypoxia always involves averaging over very large numbers of cells. • Hypoxic cells are likely to exist in all imaging voxels • It will never be possible to deliver dose specifically to hypoxic cells