BCRB 2018

19/09/2018

Hypoxia and vessels in H&N cancer biopsies

SCCNij51

SCCNij85

SCCNij47

HF: 7.2%

HF: 0.3%

HF: 5.6%

1 mm

SCCNij76

SCCNij78

SCCNij68

37

HF: 13.8%

HF: 17.2% HF: 7.2%

Loco-regional tumor control after RT: hypoxic vs non-hypoxic tumors

prognostic indicator

predictive assay

100

100

ARCON

oxic

RT alone

80

80

ARCON

60

60

hypoxic

40

40

RT alone

20

20

Loco-regional control (%)

p = 0.01

0

0

0

6

12

18 24

0

6

12

18 24

Time (months)

Kaanders et al. Cancer Res 2002