BCRB 2018

19/09/2018

Patient selection

Swartz JE et al Cancer Med 2015

Hypoxia-modified treatment schedules for patients with high expression of endogenous hypoxia markers

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Take home messages

• Hypoxic cell radioresistance is a significant cause of faillure in local tumor control in particular in SCC of head and neck and uterine cervix • Using high oxygen content gas breathing, chemical radiosensitizers or blood transfusion have shown mixed results • Meta-analysis of randomized trials does however demonstrate a significant benefit and level 1a evidence for head and neck tumors

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