BCRB 2018

NTCP models

Lyman model (power law, 4 parameters)

More quantitative data

Kutcher-Burman (KB-)model

from further (clinical) studies

Growing bone model (Krasin)

for individual endpoints

Tissue architecture models

are required !!!

Serial architecture/critical element

Parallel architecture/critical volume

ESTRO BCR Course / Volume effect in RT – W. Dörr