BCRB 2018

19/09/2018

Target driven lethality

5

Target driven lethality

• High specificity • Low toxicity (different from RT) • Interaction with RT • Radiosensitivity • Hypoxia • Proliferation • Immune activation • Therapeutic index • Target driven • Synthetic lethality • Contextual lethality

Hanahan & Weinberg Cell 2011

6

3