BCRB 2018

19/09/2018

EGFR inhibition + RCT in HNSCC

• Benefit with chemotherapy ? RTOG0522 trial • Randomized Phase III, stage III and IV HNSCC • Concurrent accelerated radiation + cisplatin (arm A; n = 447) vs concurrent accelerated radiation + cisplatin + cetuximab (arm B; n = 444)

• Adding cetuximab to radiation-cisplatin did not improve outcome; leads to more acute grade 3-4 toxicity

Ang KK, JCO 2014;32:2940

10