BCRB 2018

19/09/2018

EGFR inhibition + RCT in rectal cancer

• CRT might have been compromised by cetuximab pretreatment • Pre-CRT initial dose of cetuximab decreased tumor cell proliferation • Capecitabine needs to be taken up by proliferating cells to exert its effects

Debucquoy JCO 2009

27

Synthetic lethality

• High specificity • Low toxicity (different from RT) • Interaction with RT • Radiosensitivity • Hypoxia • Proliferation • Immune activation • Therapeutic index • Target driven • Synthetic lethality • Contextual lethality

Hanahan & Weinberg Cell 2011

28

14