BCRB 2018

Conventional treatment (6 weeks overall time)

100

Example: protraction of overall treatment time is detrimental! Balancing risks and benefits: The therapeutic window

80

60

Tumour

40

Late oedema

20 Response (%)

0 30 40 50 60 70 80 90

Radiation dose (Gy)

100

Split-course treatment (10 weeks overall time)

80

Tumour

60

40

Late oedema

20 Response (%)

0 30 40 50 60 70 80 90

Bentzen and Overgaard (1996)

Radiation dose (Gy)

Michael Joiner

Basic Clinical Radiobiology 2018

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