BCRB 2018

Lyman model of dose-volume effects in normal tissue

NTCP ( D , v ) = 1 2 π ⋅

−∞ u ( D , v ) ∫

exp( − x 2 /2) dx

D − D m ⋅ D

( v )

0 < n < 1 Larger n , more volume effect

u ( D , v ) =

50

( v )

50

(1)

D

( v ) =

D

50

( see BCR5 book, Ch 7.6 )

50 v n D 50 = uniform dose producing 50% incidence of specific effect n = denotes influence of volume effect in organ of interest m = inverse of dose response curve gradient

Michael Joiner

Basic Clinical Radiobiology 2018

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