Basic Clinical Radiobiology 2017
HIF and cancer
• Loss of VHL causes overexpression of HIF and renal cell carcinoma • HIF is overexpressed in many cancers – Mimics hypoxia biology in normoxia
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HIF and cancer
• Loss of VHL causes overexpression of HIF and renal cell carcinoma • HIF is overexpressed in many cancers – Mimics hypoxia biology in normoxia
Made with FlippingBook - Online Brochure Maker