Basic Clinical Radiobiology 2017

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Hypoxic severity affects cellular response

• Tumors

• Normal tissue

“ Mild ” hypoxia

Acute ( “ extreme ” ) hypoxia

“ Moderate ” hypoxia

•Normoxia

• [O 2

]

•0%

•0.1%

•1%

•3%

•5%

HIF-1

UPR

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