Basic Clinical Radiobiology 2017

ARCON for cT2-4 larynx carcinoma

Randomization

Accelerated Radiotherapy + carbogen and nicotinamide

Accelerated Radiotherapy

Fractionation schedule:

primary

metastatic nodes

Acc. RT ARCON

68 Gy

68 Gy 68 Gy

64 Gy*

*Aim: improve tumor control with equal toxicity between arms!

48

Janssens et al., J Clin Oncol 2012