Basic Clinical Radiobiology 2017

Back to the future: SBRT & tumor hypoxia

• With the developments in image-guided radiotherapy (IGRT), the use of high single doses or a few large fractions is rapidly gaining popularity in the clinic • Stereotactic Body RadioTherapy (SBRT) is now widely used for early stage lung cancer, but also metastases in various sites • One reason fractionated radiotherapy became standard was the absence of a therapeutic window with large single doses, predominantly because of hypoxia!