Basic Clinical Radiobiology 2017

CHHiP-trial • Acute toxicity: greater peak for acute bowel toxicity • Late toxicity: no significant differences between the 74 Gy and the 60 Gy group

• Bowel symptoms peaked sooner in hypofractionated schedules

• RTOG grade 2 or worse bowel toxicity - 74 Gy: 25% - 60 Gy: 38% - 57 Gy: 38%

Dearnaley et al. Lancet Oncol. 2016