Basic Clinical Radiobiology 2017

Radioimmunotherapy combinations

• 3 main clinical scenario’s • IT + hypofractionated RT for oligometastatic disease

• Clinical goal: reduce distant failures (effect outside radiation field) • Mechanism: in situ vaccination effect coupled to local and systemic effects IT • IT + chemoRT • Clinical goal: enhance efficacy of chemo-RT locally and reduce distant failures • Mechanism: local and distant synergies between RT and immunomodulation • RT + IT • Clinical goal: maximize efficacy of IT against specific tumor deposit (effect within radiation field) • Mechanism: RT = biological response modifier