Basic Clinical Radiobiology 2017

Introduction

• Reirradiation of previously treated areas: why? – New primary tumor • Cancer survivors are at an increased risk of developing secondary malignancies – Pts still retain more risk (e.g. molecular predisposition) – Aetiological factors can continue (e.g. Smoking) – Therapy itself • Within or close to initial high-dose treatment volume – Recurrence • Within or close to original gross tumor volume – Nodes and metastases