Basic Clinical Radiobiology 2017

Urinary bladder (mouse) • Original tolerance restored between 25-50 days

30

initial RT: 5x5.3 Gy / 5 d

25

First treatment: 5 × 5.3 Gy over 1 week Endpoint: 50% reduction in bladder storage capacity at 1–3 weeks post retreatment

20

10 Retreatm t D 50 (Gy) 15

retreatment alone

5

Retreatment ED50 [Gy]

0

0

20

40

60

80

100 120

14 Time to reirradiation [days] Time after first treatment (days)