Basic Clinical Radiobiology 2017

Summary experimental data

100 120

0 20 40 60 80

early effects

Reirradiation dose (% of EQD tol ) skin/oral mucosa

lung pneumonitis

late effects

Modified from Stewart FA & van der Kogel AJ Semin Radiat Oncol 1994

kidney (bladder) (heart?)

20 40 60 80 100

spinal cord

0 20 40 60 80 100 0

0 20 40 60 80 100 120

Initial dose (% of EQD tol )

Several, but not all, normal tissues are able to tolerate considerable retreatment with radiation