Basic Clinical Radiobiology 2017

Validation study in locally advanced HNSCC

Use of FDG-PET for target volume delineation in 3D- CRT/IMRT for head and neck tumors

• GTV-T FDG-PET • CTV-T FDG-PET • PTV-T FDG-PET

< GTV-T CT < CTV-T CT < PTV-T CT

(oropharyngeal SCC) • More parotid sparing with the use of FDG-PET (oropharyngeal SCC) • Loco-regional control probability within the expected range

ESTRO 2017

Grégoire & Leclerc, 2013

Validation study in locally advanced HNSCC

• Local relapse: 9/41 - No marginal recurrence (i.e. in the CTV CT

and not CTV PET )

• Regional relapse: 2/41 • Metastasis: 6/41 • Second primary: 2/41

ESTRO 2017

Grégoire & Leclerc, 2013