Basic Clinical Radiobiology 2017

Reduction of radiosensitivity differences : Potential therapeutic advantage when the tumor is radioresistant in comparison with healthy tissues

Tumor

Tumor

Healthy tissues

HT

Dose (low LET) Surviving Fractions (%)

Dose ( high LET) Surviving Fractions (%)

Potential therapeutic benefit due to the reduction of an unfavourable differential effect

ESTRO 2017

Reduction of radiosensitivity differences : contra-indication when the healthy tissues are radioresistant In comparison with the tumor

Healthy tissues

Healthy tissues

Tumor

T

Surviving Fractions (%) Dose (low LET)

Surviving Fractions (%) Dose ( high LET)

Contra-indication due to the reduction of a favorable differentiel effect

ESTRO 2017

Ion beam therapy: clusters of DNA damages

ESTRO 2017

Mohamad et al, Cancers, 2017

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