Basic Clinical Radiobiology 2017

PROTON THERAPY: CLINICAL RESULTS

NUMBER OF PATIENTS ofpatients

D RBE Gy (RBE)

PRIMARY TUMOR

LOCAL CONTROL

REFERENCE

990 1922

99 %at5 yr 96 %at10 yr

Egger etal . (2001) Gragoudas et al . (2002) Liebsch, N., Personal communication (2005) Terahara etal . (1999)

Uveal melanoma

70 in5 Fx

Skull base chondrosarcoma

~ 69

202

95 %at10 years

Chordoma

~ 69

132 202

59 % / 44 %at5 / 10yr 80 %vs. 92 %at5 yr 60 %vs. 77 %at8 yr 75 % / 73 %biochemical disease-freesurvival at 5 / 8yr

ProstateTIII -TIV (photons ± protonboost)

67.2 vs. 75.6 (Phase III trial)

Shipley etal . (1995)

Prostate TIa -TII

74

1255

Slater et al . (2004)

ProstateTI - TII (photons ± proton boost) 70.2 vs. 79.2

393

61.4%vs. 80.4%at5 yr Zietman etal . (2005)

Non-small cell lung cancer. Stage I

73.8

27

86%at2 yr

Bush et al . (2004a)

72 (16Fx in 29days) 63 (15Fx in 3 weeks)

162 34

87 %at5 yr 75%at2 yr

Chiba et al . (2005) Bush et al . (2004b)

Hepatic cancer

34 % / 18 %survival at 2 / 3yr

Glioblastomamultiforme 90BID in 5weeks 23

Fitzek etal . (1999)

Adenocysticcarcinomaof theparanasal sinus

76  surgery

23

93%at5 years

Pommier et al . (2005)

Axial skeleton: Chondrosarcoma Chordoma

72.2 74.6

6 14

100%at 5yr 53%at5 yr

Hug etal . (1995)

ESTRO 2017

29