Basic Clinical Radiobiology 2017

All studies using morphology or TUNEL since 2000 (Wilson, 2003)

Cervix

author n, treatment

result

comment

Jain

76, Rx

n.s. n.s n.s. sig sig sig n.s. n.s. sig sig sig sig sig n.s n.s. sig n.s. sig sig n.s. n.s. n.s n.s. sig sig

no correlation with either p53 or bcl-2

Gasinska 130, Rx

AI/MI index significant

Lee Kim Liu

86, ?

correlation with progression, MVD, Ki-67 but not OS

42, Rx 77, Rx 40, Rx

high AI poor LTC, OS

high AI (or Ki-67) poor OS no corr with IATs low AI poor OS (or high vascularity)

Zaghloul high prolif or grade significant Results 6 better outcome with high AI 8 worse outcome wi h igh AI 13 not significant 58, surg Hwang 68, surg Macluskey ?, ? Langedijk 161, Rx Srinivas ?, ? low AI worse OS high AI worse DFS, OS correlated with p53 and MI only MI and grade significant Kato Ikpatt Villar 422, ? 585, ? 116, surg Lee Wu 82, ? positive correlation with PCNA low AI worse RFS and OS 91, CTX Wang Paxton 146, Rx

NSCLC Hanaoka 70, surg

no correlation with bcl-2 or bax or ratio

low AI worse OS inverse correlation with bcl-2 and TA low AI worse OS also high bcl-2 worse OS

high AI worse LTC, OS no correlation with bcl-2

Breast

high AI worse survival inverse corr with bcl-2

de Jong 172, ? Lipponen 288. ?

high AI worse OS positive correlation with MI

high AI worse OS

Rectum Sogawa 75, pre Rx

AI increased after Rx but not correlated with OS inverse correlation with p53 and bcl-2

Schwander 160, surg

Bladder Giannopolou 53, ?

no correlation with pro-apoptotic proteins bax, FAS-R casp-3 high AI better LTC not OS, low AI shorter time to reccurrence

Moonen 83, Rx

Lara Rees

55, Rx

low AI better LTC and OS

Esoph

58, Rx, CTX, surg n.s

only TOPO II and not AI or Ki-67 showed clinical utility

Shibata 72, surg

sig

high AI better OS