Basic Clinical Radiobiology 2017

Withers 1966: Skin remains intact if clonogen survival is higher than about 5 per 10 -6 per cm 2 . Higher doses will cause moist desquamation. Dose-response for skin epithelium

Two clonally-derived islands of epithelium in a 1 cm diameter radiation-induced ulcer of the skin on the back of a mouse. Rapid regrowth on epithelial surfaces such as skin and mucosa provide a reason for protracting radiation therapy over several weeks.

20 days after 15Gy

hypoxia

Dose-survival curves for mouse skin epithelial clonogenic (stem) cells in conditions of hyperbaric oxygen, air breathing or ischemic hypoxia induced by compression.

air

oxygen