Basic Clinical Radiobiology 2017

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Conventional fractionation 1.8 – 2.0 Gy per fraction, 5 fractions per week IIIII IIIII IIIII IIIII IIIII IIIII IIIII

Example

Dose (Gy)

Tumor control (%)

Seminoma, Lymphoma

£ 45

³ 90

Sensitive

SCC, Adeno-Ca

50 60 70

³ 90 (subclinical) ~ 85 (Ø 1 cm) ~ 70 (Ø 3 cm) ~ 30 (Ø 5 cm)

Intermediate

Glioblastoma Melanoma

³ 60 ≥ 60

none? none?

Resistant

ESTRO 2017

40 120 Tumor control (%) Dose-response curve for neck nodes ≤ 3 cm Tumor Control Probability (TCP) 60 80 100

20

,

0

45

55

65

75

85

95

Total dose (Gy)

ESTRO 2017

Bataini et al, 1982

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