Basic Clinical Radiobiology 2017

Hyperfractionation (HF) reduced dose per fraction (< 1.8 Gy)

CF

HF

70Gy/ 2.0 Gy/ 7w

80.5Gy/ 2x1.15 Gy/ ti=6h/ 7w

Expectations (dose-escalated HF): • Increased tumor control •More severe early reactions •Unchanged or less late reactions

ESTRO 2017

EORTC Hyperfractionation trial in oropharynx cancer (N = 356)

Oropharyngeal Ca T2-3, N0-1

80.5 Gy - 70 fx - 7 wks vs 70 Gy - 35-40 fx - 7-8 wks

p = 0.02

p = 0.08

SURVIVAL

LOCAL CONTROL

Years

Years

ESTRO 2017

Horiot 1992