Basic Clinical Radiobiology 2017

Tissue proliferation and recovered dose D prolif

Tissue

D prolif (Gy.d -1 )

T k * (days)

Early normal tissue reactions Skin (erythema)

0.12 (-0.12-0.22) 0.8 (0.7-1.1) 0.54 (0.13-0.95)

< 12 < 12 n.a.

Mucosa (mucositis) Lung (pneumonitis)

Tumors

Head and neck • larynx

0.74 (0.3-1.2)

n.a. 30 21 n.a. n.a.

• tonsils • various • various

0.73

0.8 (0.5-1.1) 0.64 (0.42-0.86)

NSCLC

0.45

Medulloblastoma

0.52 (0.29-0.71

0 – 21

* onset of accelerated proliferation

ESTRO 2017

Bentzen et al, 2002

Influence of overall treatment time on HNSCC local control

6 weeks 10 weeks (3 w gap)

100 80 60 40 20 0

60 Gy

72 Gy

57 Gy

68 Gy

Tumor control (%)

50 60 70 80 90 40

Total dose (Gy)

ESTRO 2017

Overgaard et al, 1988