Basic Clinical Radiobiology 2017

Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomized, multicentre trial

IIIII IIIII IIIII IIIII IIIII IIIII IIII 66-70 Gy/ 2.0 Gy/ 6.5-7.0 w

IIIIII IIIIII IIIIII IIIIII IIIIII IIIIII 66-70 Gy/ 2.0 Gy/ 5.5-6.0 w

ESTRO 2017

Overgaard et al. Lancet Oncol, 2010

EORTC - Head & Neck (22851) SCC, T2-4 N0-3 M0, WHO 0-2 (n=500)

IIIII IIIII IIIII IIIII IIIII IIIII IIIII 70 Gy/ 1.8-2.0 Gy/ 7 w (n=253)

IIIII I IIIII IIII IIIII I IIIII IIII IIIII I IIIII IIII 72 Gy/ 3 x 1.6 Gy/ ti 4 h/ Pause 12-14d/ 5w (n=247)

Accelerated RT: • Tumor control increased • Survival identical • Very severe early NT reactions

ESTRO 2017

Horiot et al., Radiother. Oncol. 44: 111-121, 1997