Basic Clinical Radiobiology 2017

Hypofractionation in NSCLC

ESTRO 2017

Martin et al., 2010

Conclusions

• Benefit of hyper- and accelerated fractionation for loco- regional control probability • Slight increase in acute toxicity but no change in late toxicity • Moderately hypofractionation for tumors with low a/b • Extreme hypofractionation for well selected indications, e.g. small peripheral lung tumors (dose distribution effect only!)

ESTRO 2017