Basic Treatment Planning

Oropharyngeal Cancer and Human Papilloma Virus

• HPV-DNA detected in 15-62% HNSCC, higher in oropharynx

• Patients with HPV +ve oropharyngeal canrcinoma - Typically younger - Non-smokers and Non-drinkers - LN mets have a firm rather than hard consistency - Tumour shows basaloid features - +ve for p16 on immunohistochemical staining - Outcome is better than non-HPV related carcinomas Rischin D, Young RJ et al. J Clin Oncol. 2010 Sep 20;28(27):4142-8.