Brachytherapy for Prostate Cancer 2017

Dynamic Contrast-Enhanced MRI Assessment of Angiogenesis

Enhancement

Lesion Morphology

Angiogenic Factors

Increased in- en efflux Expanded extracellular space Increased extravasation

Growth of existing vessels De novo angiogenesis

Abnormal configuration: AV-shunts and defective endothelium

Earlier onset of enhancement Increased slope