Brain 17 Vienna

Gross Total Resection impacts natural history of low-grade gliomas

• Malignant transformation ranges between 4 and 29 months • 45% of WHO grade II undergo anaplastic tranformation in 5 years

• If resection > 90% 

Median time to progression: 5.5 years

Median time to malignant transformation: 10.1 years

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 5yy survival rates is 97% (vs 76% if extent of resection <90%)

Smith JS, Chang EF, Lamborn KR, Chang SM, Prados MD, Cha S, Tihan T, Vandenberg S, McDermott MW, Berger MS (2008) Role of extent of resection in the long-term outcome of low- grade hemispheric gliomas. J Clin Oncol 26:1338–1345