Brain 17 Vienna

PHYSIOLOGICAL IMAGING PERFUSION MRI

• Provides hemodynamic informations and estimates the cerebral blood volume that reflect the underlying microvasculature, marker of angiogenesis • Exploit signal changes that accompany the passage of a paramagnetic contrast agent thorugh the cerebrovascular system • Useful if patients receive antiangiogenetic cancer therapies to monitor its efficacy • Maps of cerebral blood volume can serve as an additional targets for brain tumour biopsies • May help in differentiating radiation necrosis and recurrent tumour • May help differentiating tumor infiltrated edema (high grade gliomas) and vasogenic edema (in case of metastases)

PITFALL: NO CORRELATION WITH TUMOR GRADING

Di Stefano et al. 2014