Brain 17 Vienna
Studies on neuro-toxicity in gliomas
Author year
Setting Tumor Nr
Dose Resp.
Tumor PD Worsening of NC Significant improvement
Taylor
1998
Pro
HGG
701
60Gy
No significant Neurotoxicity Worsening at 1, 2, 5 years: 8.2, 4.6, 5.3%
Brown
2001
Pro
LGG
203
50.4 vs 64 Gy
59%, 50%, and 67% at years 1, 2, and 5,
Armstrong
2000
Pro
LGG
20
46-63 Gy Verbal decline at 3m, recovery at 1y
-
Vigliani
1996
Pro
LGG
17
54-55.8 Gy
No tox compared to matched pairs, improvement* No significant impairment
-
Klein
2001
Retro
LGG
195
n.r.
n.r.
Taphoorn
1994
Retro
LGG
41 (20 RT/21 Sg only)
45-63 Gy No difference Comparison to 19 haem dis. CHT,LGG both groups with lower Cog/mood/asteni a
-
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