Brain 17 Vienna
Chemotherapy and the BBB
Drug
CSF penetration
Nitrosoureas (ACNU,BCNU; CCNU, Fotemustine)
++
Procarbazine
++
Thiotepa
+
Dacarbazine Temozolomide
(+) ++ +/- ++ -/+ - ++ -/+ -/+
Cyclophosphamide, Ifosfamide
AraC
Methotrexate
5-FU
(++)
Anthracyclins Liposomal doxorubicine
VM26
Etoposide
Vincaalkaloids, Taxanes
-
Topotecan
++
Cisplatin, Carboplatin
-
Müller et al., Malignant brain tumors 1995
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