Brain 17 Vienna

PHYSIOLOGICAL IMAGING MRI SPECTROSCOPY

Provides insight into the biochemical profile

• NAA : marker of neural integrity • Choline : membrane turnover • Creatine: energetic • Myoinositol : astrocytic marker • Lipid : tissue destruction/necrosis marker • Lactate: hypoxia marker • Glutamine and Glutamate: excitatory markers

High choline correlates with high tumor proliferative index Lower grades are associated with elevated MI/Cr ratio

Pitfalls : - min 1 cm3 voxel size

- not suitable for posterior fossa lesions and lesions near bone - common aspecific spectral findings