Brain 17 Vienna
Temozolomide
• Imidazotetrazine derivative of dacarbazine • Conversion in the systemic circulation at physiological pH to the active compound, 3-methyl-(triazen-1-yl)imidazole-4-carboxamide (MTIC) • Good BBB penetration • Oral application (note: there is also an i.v. formulation) • Methylation of O6 guanine:
Tumor cell death
03/01/13
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